Journal: PLoS ONE
Article Title: Sulforaphane Bioavailability from Glucoraphanin-Rich Broccoli: Control by Active Endogenous Myrosinase
doi: 10.1371/journal.pone.0140963
Figure Lengend Snippet: Preparations are: SF-, GR-, or GR plus Myrosinase-rich; they are delivered either in water, juice, or gel-caps; and they are derived from either sprouts or seeds, as indicated at top of graph. Boxes around data points delineate the 25 th to 75 th percentile of values, and whiskers delineate the 5 th and 95 th percentiles. Solid line through middle of box is the mean. “Cohort numbers” in the following are from : (A) Hospitalized subjects given SF-rich BSE (mean 68.9%, data from Ref. ); (B) Hospitalized subjects given GR-rich BSE (mean 18.0%, data from Ref. ); (C) Free-living subjects given GR-rich BSE (mean 11.8%, data from Ref. ); (D) Cohort 1 (BSE in water; mean 9.4%); (E) Cohort 3 (Xymogen BSdE in gel-caps; mean 10.4%); (F) Cohort 2 (JHU BSE in gel-caps; mean 10.3%); (G) Cohort 6 (FDBS in dilute pineapple-lime juice; mean 44%); (H) Cohort 5 (FDBS in acid-resistant gel-caps; mean 32.7%); ( I) Cohort 5 (FDBS in regular gel-caps; mean 35.1%); (J) Cohort 4 (BSdP; 35.9%). There is a highly significant difference between the means of D through F a (10.3%), and G through J b (39.6%), (p = 0.0000, by oneway anova).
Article Snippet: Two types of highly standardized, lyophilized boiling water extracts of 3-day-old broccoli sprouts (BSE) have been prepared at Johns Hopkins University Medical School (JHU), utilizing good manufacturing (GMP) conditions, and have been used widely under clinical protocols approved by IRBs and under INDs approved by the FDA.
Techniques: Derivative Assay